“Endocrine disruptors are chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife” . According to a 2006 report by the National Research Council, fluoride is an endocrine disruptor:
“Evidence of several types indicates that fluoride affects normal endocrine function or response; the effects of the fluoride-induced changes vary in degree and kind in different individuals. Fluoride is therefore an endocrine disruptor in the broad sense of altering normal endocrine function or response, although probably not in the sense of mimicking a normal hormone. The mechanisms of action remain to be worked out and appear to include both direct and indirect mechanisms, for example, direct stimulation or inhibition of hormone secretion by interference with second messenger function, indirect stimulation or inhibition of hormone secretion by effects on things such as calcium balance, and inhibition of peripheral enzymes that are necessary for activation of the normal hormone” .
“The endocrine system is a collection of glands in the body that secrete hormones–chemical signals that regulate the function of numerous cells and organs in the body” . Given the wide ranges and overall increases in fluoride exposures following artificial fluoridation programs , the important issue of margin of safety naturally arises .
 National Institutes of Health, Endocrine Disruptors.
 National Research Council, Effects on the Endocrine System – Fluoride.
 FAN, Fluoride & Endocrine System.
 AFAM, Dose vs. Concentration.
 Margin of Safety, Overview.